SWOT Analysis of Toys “R” Us
A SWOT analysis of Toys “R” Us can be used to curve a clear, sustainable niche in the target market of this company. SWOT analysis can be defined as a useful technique that enables managers and policymakers to understand the strengths as well as weaknesses of an organization while identifying the available opportunities and threats that the organization is facing. Toys “R” Us can perform a SWOT analysis and use it to uncover opportunities that this organization is capable of exploiting. Additionally, this analysis can be used to identify and understand the weaknesses that the organization is facing as well as in managing and eliminating threats that may otherwise catch it unawares.
A clear SWOT analysis of Toys “R” Us
Toys “R” Us is a retail company that was founded in 1957 by Charles Lazarus in Rockville, Maryland, U.S. Currently, this firm is headquartered in Wayne, New Jersey. It has different outlets in Canada, Finland, Africa, Europe, Asia and Oceana.
Its SWOT analysis is as follows:
- Toys “R” Us offers a wide array of baby amusement items and toys.
- Its chain comprises of 840 stores in the U.S only, with operations in 34 countries and 716 stores.
- The franchises chain and licenses of this company have also made it very popular.
- It is the second-largest retailer in the United States.
- Its toys brand is popular globally.
- It has a properly developed e-commerce website that facilitates online purchases by customers. It has numerous e-commerce sites including eToys.com and babyuniverse.com that are not only well managed but also attractive.
- It has created jobs for 70,000 people across the world.
- Toys “R” Us lacks a competitive advantage because it is a sole source brand. Its only competitor is Wal-Mart which is offering attractive offers.
- It does not offer unique toys because you can find similar items in better packages with different brands.
- Its sales are season-dependents because the range of the products that it offers is not attractive during other seasons apart from Christmas. This is why its sales keep declining despite being the sole global toy chain store and having a strong brand.
- After Express locations gave this company positive response, it decided to open more with about 600 stores.
- The company has been able to excel after forming an alliance with Amazon, its competitor. This alliance encouraged the buying power of the company but it came with physical stacking risk.
- Through charitable giving, the company can enhance its popularity through several side by side campaigns.
- The company’s revenue can be enhanced by diversifying locations if introduced in countries like India and China which are the emerging economies.
- Affiliated chains like Kids “R” Us, Bike “R” Us, Scoops “R” Us and KB Toys are also presenting opportunities to the emerging markets and this company too.
- Strong competition particularly from Wal-Mart and other retailers.
- Low cost toys such as those from Chinese manufacturers are a threat to the manufacturers who spend on high costs’ raw materials.
- Many brands to choose from mean that the company must offer attractive packages to customers.
- By closing chains suddenly including its 87 stores, the firm indicated that the label was unreliable because it fired several employees.
- The company’s payment disputes over the last two years gave the brand a negative image because the media highlighted it.
What makes SWOT analysis of Toys “R” Us important
Toys “R” Us can use a SWOT analysis in two ways. The management can use it as an icebreaker that helps the management to start the process of formulating strategies or as a strategy tool. Using this analysis, the management of Toys “R” Us company can understand the competitors of this company better and gain vital insights that will enable them to formulate strategies that will enhance its competitiveness.
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Nicotinamide Adenine DinucleotidPhosphate
Nicotinamide adenine dinucleotide phosphate is a coenzyme form of vitamin niacin. The enzyme also known as NADP is needed for many biochemical reactions to take place. Protein catalysts including trypsin and lysozyme catalyze different reactions by themselves. However, many other catalysts require metal ions as well as ribonucleic acid to carry out a reaction.
Niacin is a component of nicotinamide adenine dinucleotide phosphate and NAD. These enzymes are very crucial in catabolism, and in the production of energy as well as biosynthesis of sugars and fats.
Nicotinamide adenine dinucleotide phosphate is therefore very important and plays a crucial role in ensuring that biochemical reactions take place. Redox reactions for instance cannot take place without NADP. This is a reaction in which oxidoreductase enzymes transfer hydrogen.
Redox reaction is catalyzed by nicotinamide adenine dinucleotide phosphate or the oxidoreducrase enzyme. During the process, two electrons and two hydrogens are removed from an ethanol molecule. A hydrogen atom and two electrons will then be transferred to generate an active NADP+.
Enzymes that require NADP to carry out different reactions
- Alcohol dehydrogenase requires NADP to metabolize alcohol
- Glyceraldehyde phosphate dehydrogenase needs NADP to catalyze an important step in glycolysis
- Lactate dehydrogenase also requires NADP to catalyze reactions in liver and muscle cells
- Pyruvate dehydrogenase needs NADP to catalyze any reaction connecting to glycolysis to the Krebs cycle
- a-keto-glutatarate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase also require NADP to catalyze oxidative phosphorylation reactions
- Hydroxyl-acyl-sCoA dehydrogenase needs NADP to catalyze oxidative phosphorylation reactions
- Glucose 6-phosphate dehydrogenase is also needed to catalyze reactions in pentose phosphate pathway, in the Calvin cycle and in fatty acid synthesis.
Additionally, biosynthetic and energy producing functions of Glucose 6-phosphate dehydrogenase also come in handy. The enzyme act as an electron acceptor in oxidoreductase catalyzed reactions. It acts as an electron donor to ensure successful reactions in different cycles and metabolic processes.
Glucose 6-phosphate dehydrogenase can also act as a side enzyme in different reactions. This depends on the side of NAD molecule that the enzyme acts on. For instance alcohol dehydrogenase catalyzes an alcoholic reaction. NADP therefore acts as a side enzyme by ensuring sufficient transfer of hydrogen from ethanol and to the position that is required to produce quality alcohol.
Similarly, nicotinamide group can be used with dehydrogenase enzyme unexpectedly to complete a catalytic reaction. It is also important to note that NADP has a very distinctive signal in ultra-violet spectroscopy. The enzyme is used by scientists to monitor a wide range of enzyme catalyzed reactions.
Who established Glucose 6-phosphate dehydrogenase?
Glucose 6-phosphate dehydrogenase is an enzyme that has been proven to be very important in a wide range of metabolic reactions. This is an enzyme that was first established by Hans von Euler. He was the first to realize the structure of the enzyme. In 1929, Hans shared a Nobel Prize with Arthur Harden in medicine and in physiology for the discovery of the enzyme as well as NAD.
Later on, Euler proved that NAD contains two phosphate groups including one adenine, one nicotinamide unit and ribose sugar. These are important compounds that offer a positive charge on the enzyme and nitrogen atoms in different reactions.
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Multidrug Resistance Associated Protein 1
Multidrug resistance associated protein 1refers to a protein that is encoded by ABCC1 gene in humans. The protein that is encoded by ABCC1 gene is part of the genes that belong to a super-family of the ATP-binding cassette or ABC transporters. ABC proteins are responsible for the transportation of different molecules across the intra and extra-cellular membranes.
There are seven divisions or distinct subfamilies of the ABC genes. These are the ABC1, MRP, MDR/TAP, OABP, ALD, GCN20 and White. Multidrug resistance associated protein 1is a full transporter belonging to the MRP subfamily that is involved in the multi-drug resistance activities. The function of this protein is to act as multi-specific organic anion transporter with the oxidized glutathione, activated aflatoxin B, and cysteinly leukotrienes as the substrates.
The protein is also responsible for transporting sulfate conjugates and glucuronides of the steroid hormones as well as bile salts. Different splice variants result from alternative splicing of the exon deletion but original reading of the open frame in all the forms is maintained.
Multidrug resistance associated protein 1is among the major obstacles when it comes to treatment of cancer. This is because it not only hinders treatment, but also proper prognosis of cancer patients. It transport different therapeutic agents and a wide range of physiological substances and it can also play a significant role in development of resistance to drug in different forms of cancer including prostate cancer, breast cancer, lung cancer and childhood neuroblastoma.
Many patients of neuroblastoma in the current world disseminated this disease during diagnosis. Despite undergoing intensive treatment, prognosis of such patients remains dismal. Evidence that shows that multidrug resistance associated protein 1targets the genes that are involved in multidrug resistance in the neuroblastoma is increasing rapidly. Considering the significance of multidrug resistance associated protein 1overexpression in the neuroblastoma, its inhibition can be an important approach clinically in improving the patient outcome in the disease.
Developing a resistance to different cytotoxic drugs is the main cause of failure for treatment in different types of infections and malignant diseases. Thu, despite making significant advancement in the treatment of cancer, multidrug resistance associated protein 1is still a major problem in the medical or clinical field.
It causes poor outcome for patients and limitation of therapeutic options in different cancers. As such, having a better understanding of mechanisms leading to multidrug resistance associated protein 1is very important. It can help in improving the existing regime of chemotherapy in treatment of cancer and neuroblastoma.
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An Easy way of how to write a thesis statement for an essay
A thesis statement is a condensation of your argument or main idea. In academic writing, your thesis statement should appear towards the end of your introduction paragraph. In most cases, a thesis is a single sentence that summarizes the rest of your paper. However, in some cases, especially when writing very long papers, a thesis could be several sentences or a paragraph. Importantly, no essay is complete without a thesis statement. Thus, whether you are preparing to tackle a short essay or your PhD dissertation, you must have the tips of how to write a thesis statement for an essay at your fingertips. This will ensure that you do not go off the tangent as you put together your ideas.
This document will take you through different steps that will help you develop awesome thesis statements whenever you are writing academic essays. Here is what is coming up….
- Importance of a thesis statement
- Developing a thesis statement
- Making your thesis strong
- Examples of thesis statements
Read on and get the facts right…
The basics of how to write a thesis statement for an essay and why you need one
When writing an academic essay, it is important to state the purpose of your paper. The reader wants to know why you writing on the topic. This purpose should come early in your paper to help your audience understand your argument better. Do not hide the aim of your assignment. Here are the functions of an effective thesis statement
States the function of your paper- A thesis should clearly define what you are discussing. What is your argument?
Determines the structure of your paper – An effective thesis statement will dictate the order of your ideas and supporting evidence. This is essential in shaping the structure of your final draft.
Strengthens your argument – One can only tell the strength of your argument by looking at your thesis statement. Use this statement to win your audience by making it captivating.
It guides your audience – As you think about how to write a thesis statement for an essay, have in mind the needs of your readers. A good thesis acts as a compass to you as the writer and as a guide to the reader. It ensures that you are moving together without any disconnect.
With this introduction, let us look at sample thesis statements before we move to the next section:
Example #1: Sample thesis Statement
“Admission panelists in colleges experience a dilemma of admitting students who have high-test scores or those with strong extracurricular backgrounds”.
This is an analytical thesis statement from OWL. If someone were reading an essay with this thesis, he or she would expect the essay to discuss the following in details:
- The process of admitting students in colleges
- Challenges which admission panelists face
Steps of how to write a thesis statement for an essay
Did you know that you could reduce every writing assignment into a single question, regardless of how it is complicated? Well, you first assignment before you start writing your essay should always be finding a suitable question that summarizes the task ahead.
Once you have the question that you are about to answer in your essay, go ahead and summarize your thoughts in two or three sentences.
Here are hints of how to write a thesis statement for an essay to help you master this better:
STEP 1: Brainstorm the topic – The first step is to look at your topic from all angles and write down the ideas, which pop in your mind. Since most of these ideas will be broad, you will have to refine them in order to turn into guiding statements.
Step 2: Narrow your topic – An effective topic is a narrow topic. A narrow topic is specific and focuses on a particular aspect of the issue. This allows you to be focused as you piece together your ideas. For example, instead of talking about Internet as your topic, refine your title. “How the internet has revolutionized communication in the 21st century” narrows down to a specific issue.
Step 3: Take your position on the topic – After narrowing to a specific topic, state what you want to discuss. For example, you may take an opposing position and support your stance throughout your paper. When taking a position, be sure to research and find out evidence backing your angle.
Step 4: Use a specific language – As you draft your thesis, do not use general or vague language. Be clear and concise with what you are saying. The reader must not have any doubts regarding your position and your discussion.
Step 5: Revise your thesis – Mastering how to write a thesis statement for an essay is about giving your best. At this stage, revisit your statement and fine-tune to make it strong and effective. Do not assume anything or leave gaps for the reader to fill. Put everything, as you would want your audience to understand. Examine the following example as you reflect on the five steps above. From the example, you should be able to visualize how the writer employed the strategies we have discussed in this section.
Example #2: Sample Thesis Statement
The following is a thesis statement of an essay titled, We Can Live Without Petroleum. The writer says:
“Petroleum offers a wide range of opportunities and advantages to humanity. However, the world can overcome overreliance oil by exploring alternative sources of energy that are renewable, cost effective and environmentally friendly.”
From this thesis statement, the reader expects the following in the essay:
- Advantages of petroleum as a source of energy
- Disadvantages of petroleum as a source of energy
- Alternative sources of energy in comparison to petroleum
This thesis is specific because it narrows to petroleum as a source of energy.
Writing a strong thesis for your essay
A strong thesis captures your argument and helps your audience to follow your ideas. It is the backbone of your paper, without which you will not accomplish your objectives. How do you make your thesis strong? This section gives you more hints on how to write a thesis statement for an essay without any struggle.
A strong thesis takes a firm stand – A good thesis should state your take on the subject. Tell your audience about your conclusions on the issue you are discussing. A statement that does not take a clear stance is weak. It is likely to give you a weak argument.
A strong thesis qualifies your discussion – Your thesis should be a pointer to your main discussion point.
A strong thesis has one idea – Do not crowd ideas in your thesis statement. Readers want to see one clear issue in your thesis. Multiple thesis statements are likely to confuse your audience. In addition, you are likely to wander as you develop your ideas and loose track.
Example #3: Sample Bad Thesis Statement
Organizations should utilize internet marketing opportunities, and online gurus can offer advertizing and customer support simultaneously.
This example has multiple ideas, making it hard for the reader to follow your argument. When you read this statement, it is not clear if the writer is discussing marketing or online companies.
A strong thesis is specific – Show exactly what you are discussing in your paper. The reader should now flip through several chapters looking for your purpose. Make it clear in your introduction.
As you discover how to write a thesis statement for an essay, it is equally important to understand common mistakes that students make. In the following section, you will learn about these errors plus ways of avoiding them.
The don’ts of how to write thesis statement for an essay
To put together a good thesis statement, avoid the following:
No thesis at all – This is a grave and inexcusable mistake. You must have a thesis statement for all your essays. In cases where your tutor is very strict, he or she may not grade your work if you do not have a thesis statement.
Avoid general statements – Sweeping generalizations are not thesis statements.
Avoid reporting facts – Scientific or documented facts are not thesis statements. Go deeper into in the matter and tell your reader why the issue is important.
Avoid announcing your thesis – Do not publicly announce your thesis. ‘This is paper will discuss A, B, and C’ is a wrong way of stating your argument.
Do not hide your thesis – Your thesis should appear towards the end of your first paragraph.
This document gives you all the secrets of how to write a thesis statement for an essay. With it, you have the key to batter writing experience. All the best.
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Strand Binding Protein
Single strand binding protein can simply be defined as protein that binds to single-stranded DNA. This Process usually takes place near the replication fork for stabilization of the single strands. The SSB protein fights towards protecting the single stranded DNA from being consumed by the nucleases through the process of digestion. Besides, it also eliminates the secondary structure from the DNA so that other enzymes are able to effectively operate upon it.
Single stranded DNA can always be produced in every aspect of DNA metabolism. Such aspects include replication, repair and recombination. Single strand binding proteins are joined to numerous proteins that are involved in all processes of DNA metabolism. Besides, they are also very active in the modulation of these proteins. It should be noted that single strand binding proteins do not bind quite well to double stranded DNA.
DNA is usually stable when it is within a double helix under physiological conditions. However, this can only remain so if the complementary strands of DNA are in a similar location. After the double helix is separated by the enzyme helicase into single strands of DNA, there are higher chances that they try to re-construct the double helix. However, they need to be prevented from pursuing that course. The work of single strand binding protein is to ensure that these post-replication fork single strands of DNA do not regroup.
Single strand binding proteins are present in humans as well as bacteria and viruses. The only organisms that have not been found to contain the SSB proteins are Thermoproteales. The most ideal characterized single strand binding protein is obtained from bacteria known as E.coli. In this case, the SSB protein occupies a large number of DNA bases with regards to various factors. One of the main factors that play a role in this procedure is salt concentration.
DNA that has been changed from a double stranded form to a single stranded form can be said to have undergone denaturing. The objective of single strand binding protein is to prevent the denatured DNA from renaturing. It positions itself between two DNA strands that are undergoing replication or an individual one that is undergoing a similar process. However, emphasis is mainly placed on the latter.
A single strand binding protein ensures that even if it takes a long duration of time, renaturing of DNA does not take place. With this, there is no chance that replication of DNA shall take place. After this process, the work of the single strand binding protein is done and it is not needed anymore.
When studying single strand binding protein, it is important to also note that it binds to single stranded DNA in two different ways, limited and unlimited. Under limited, the protein clusters are only tied to the formation of dimmers of tetramers due to the interaction of four single strand binding subunits with single strand DNA. Under unlimited, there are chances of formation of long clusters of protein since they interact with one another on either sides of the protein that they are bound to.
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Retinol Binding Protein
Retinol binding protein can be simply defined as a type of protein that has a low molecular weight and transports retinol or Vitamin A from the liver to the peripheral tissues. However, it should be noted that this class of proteins can also conduct other various functions in the body. In conjunction with retinoic acid, retinol plays an important role in modulating the expression of genes as well as in the overall embryonic development. However, the supply of these substances should always be at a given level since any deficit or excess can have dire consequences that may include malformations in development or even mortality of an embryo.
The retinol binding protein helps in regulating the transportation and metabolism of retinol that is required for successful pregnancy. This class of proteins has been identified in various parts of the body including the embryo, uterus and other tissues like the porcine, ovine and bovine. This is a clear indication that retinol binding protein aids in the proper exposure of retinol to the embryo, and its transportation.
Retinol binding protein is mostly found bound to transthyretin. However, there is usually a small percentage that freely passes through the glomerular membranes. This fraction is re-absorbed by the cells of the renal proximal tubules. Under this circumstance, the small percentage of retinol binding proteins is catabolized. Due to the extensive re-absorption that takes places within the tubules, only small traces of the filtered retinol binding protein is passed out in urine. Thus, it can be said that increased excretion of retinol binding protein during the process of urination points out to an injury or impairment in the proximal tubule.
There are three types of retinol binding protein that you need to take note of when discussing this topic. One of them is called Plasma retinol binding protein that is mainly the vessel of transport in the serum. Cellular retinol binding protein is yet another type whose function is to transport retinol and factors of metabolism to retinyl esters so that they can be stored safely for future use. Besides, the factors of metabolism and retinol can also be transported to form part of retinoic acid.
Cellular retinoic acid binding proteins also fall under the three types of retinol binding proteins. Their work is to bind retinol and retinoic acid with high affinity. Besides, some studies have also indicated that this class of retinol binding proteins can also regulate and supply retinoic acid to nuclear receptors.
Retinol binding proteins are instrumental in the growth and differentiation of several body tissues. Among these, embryos are regarded as the most sensitive to changes in the concentration of retinol. The process through which retinol binding protein produces retinol is still not very clear. Retinol binding protein undergoes synthesis in the liver; however, its secretion depends on the concentrations of retinol. Secretion of RBP is usually blocked whenever there is a deficiency in retinol. This results into a rise in the Retinol binding protein levels in the liver and a fall of the same in the plasma.
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Insulin-like Growth Factor-Binding Protein
Insulin-like growth factor-binding protein refers to proteins that are secreted in vertebrates and have the affinity for binding to IGF-1. These proteins have high affinity for binding IGFs and they modulate the IGFs’ biological actions.
There are six different sub-groups of insulin-like growth factor-binding proteins that range from IGFBP-1 to IGFBP-6. Their categorization is based on gene organization, IGFs binding affinity and structural similarity.
Insulin-like growth factor-binding protein is simply called IGFBP and it acts as an insulin-like growth factor I carrier protein. About 98 percent of insulin growth factor 1 is bound to one of the six binding proteins. Insulin-like growth factor-binding protein 3 is found in the body in high amounts and it accounts for 80 percent of IGF binding.
The molar ratio of IGF-1 to IGFBP-3 is 1:1. Insulin-like growth factor-binding protein also binds to the IGF-1 in the liver. This allows the growth hormone to act on the liver so that it can produce IGF-1 continuously. IGFBPs also have inhibitor domain homologues. These are related to the family of MEROPS protease inhibitors, clan IX and equistatin.
The domain architecture of all insulin-like growth factor-binding proteins is the same. These proteins are molecules that are unusually pleiotropic. Just like the other binding proteins, insulin-like growth factor-binding protein can prolong IGFs’ half-life through their high affinity for ligands’ binding. IGFBPs share a 50 percent homology with one another. The order for their binding affinity for IGF-II and IGF-I is the same in terms of magnitude and ligands’ affinity for IGF-IR.
Individual insulin-like growth factor-binding proteins can act in a way that attenuates or enhances their similarities. However, there are cases when they exhibit different characteristics such as chromosomal location, site for RGD recognition, heparin binding domains, phosphorylation differences and glycosylation among others. Interaction of insulin-like growth factor-binding protein with the membranes of cellular basement can be affected by some of these differences.
Apart from functioning as protein carrier, insulin-like growth factor-binding proteins in serum form can regulate the actions of paracrine/autocrine and endocrine actions of IGF. They do this by modulating the availability of IGF to bind onto the signaling receptors of IGF-1.
Additionally, insulin-like growth factor-binding protein can act as a growth modulator without depending on IGFs. For instance, IGFBP-5 stimulates bone makers in the osteoblasts that lack functional IGFs. IGFBP binding to putative receptor on a cell membrane can also stimulate pathway signaling that is independent of the IGF receptor. This mediates IGFBPs’ effects on specific types of cells.
IGFBP-2 and IGFBP-1 have characteristics that enable them to stimulate the migration of CHO cell as well as human trophoblast cell via an alpha-5-beta 1 integrin-mediated action. Finally, when IGFBPs are transported into a nucleus through a nuclear localization signal they can exert effects that are independent of IGF via a genes’ transcriptional activation. Several studies have confirmed the ability of insulin-like growth factor-binding protein to influence cell growth both independently and by depending on IGFs.
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Insulin-like Growth factor 2
Insulin-like growth factor 2 is also called IGF2. It is one of the three protein hormones whose structure is similar to that of insulin. Scientists define this hormone as a neutral peptide that is well-characterized and the liver is believed to secrete it and circulate it into the blood. Among the functions of this hormone include mitogenic, insulin-like and growth-regulating activities.
This growth factor hormone depends on somatotropin although not absolutely. Many scientists believe that it is a crucial growth factor for fetus unlike the insulin-like growth factor I which is a crucial growth factor for adults. Insulin-like growth factor 2 plays an important role in influencing cell division in fetus, mammalian growth, differentiation and also metabolic regulation.
There studies that suggest that this protein promotes proliferation and growth of cells in different tissues. Studies have also proven that this protein is highly active among fetus and it facilitates their development but it is less active in adults.
Individuals inherit most genes from parents. One copy of the gene is inherited from the father and the other from the mother. The two copies are turned on or typically activated in the cells. For Insulin-like growth factor 2 gene, the copy that an individual inherits from their mother is not active in most body parts. Scientists see this as a parent-specific variation in the activation of gene and it is caused by genomic imprinting.
Insulin-like growth factor 2 forms part of a genes’ cluster found on the short arm of the chromosome 11. This part is the one that undergoes genomic imprinting. A part of DNA called the imprinting center 1 or H19 controls genomic imprinting of insulin-like growth factor 2.
A change in the insulin-like growth factor 2 due to genomic imprinting causes changes in another process known as methylation. This affects the imprinting center 1. In genes where genomic imprinting occurs, a mark or stamp is put on them during the formation of sperm or egg cells. The stamping process is what is known as methylation. It is a chemical reaction during which small molecules known as methyl groups are attached to some DNA segments.
In some individuals, this results in Beckwith-Wiedemann syndrome. This syndrome is caused by the presence of a lot of methyl groups in the DNA segments. An increase in the activities of insulin-like growth factor 2 is also associated with some strains of cancer. This occurs when both maternal and paternal copies of the gene with this protein are active.
Insulin-like growth factor 2 amount increases the rate at which cells produce. Eventually, Insulin-like growth factor 2 stimulates tumor cells’ growth while preventing the destruction of damaged cells. Other diseases that are associated with insulin-like growth factor 2 include Russell-Silver syndrome, polymorphisms and Doege-Potter syndrome.
Apart from causing these diseases, insulin-like growth factor 2 also interacts with Transferrin and IGFBP3.
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Fragile X Syndrome
Genetic syndrome disorders are quite sporadic and the Fragile X syndrome [FXS] is one of the disorders affecting 1 in 4000 males and 1 in 4000 females. FXS also referred to as Martin-Bell syndrome or Escalante’s syndrome is a common single-gene cause of autism, an inherited cause of Intellectual disability and behavioral or learning challenges. It normally affects more males than females. There are numerous causes of FXS and a number of characteristics to look at and find the best diagnosis or treatment of fragile X syndrome.
Fragile X syndrome [FXS] is associated with the growth of the CGG trinucleotide repeat that affects the fragile X mental retardation 1 [FMR1] on the X chromosome and results in a failure to easily express the fragile retardation X mental retardation protein [FMRP] essential for normal neural development. Mutations in the FMR1 cause fragile X syndrome. The FMR1gene is responsible for instructions for making protein FMRP which help in regulating the production of other proteins and in the development of synapses, specialized links between nerve cells.
Approximately all cases of fragile X syndrome are caused by mutation whereby a DNA segment CGG triplet is repeated 5 to 40 times and expanding inside the FMR1. In cases where an individual has been diagnosed with FXS, the CGG segment is repeated more than 200 times. Whenever the FMRP protein is lost, the nervous system is disturbed and fails to function normally leading to a number of FXS symptoms. In case of men or female with 55 to 200 repeats of the CGG segment FMR1 gene permutation is likely to occur. Such individuals are typically intellectually normal. Individuals with a permutation that is lower than normal amounts of the FMRP protein have mild versions of physical traits common in FXS and may experience anxiety and depression among other problems.
Intellectual disability is the most conspicuous trait of FXS. Nevertheless, there are a number of symptoms associated with fragile x syndrome. These features occur in both genders but they vary in one way or another, but they are more severe in males. The core features of fragile X syndrome in men include;
- Intellectual disability
- Large ears and long face
- Large testicles [Macroorchidism] in post-pubertal men
- Ear infections
- High arched palate
- Double jointed fingers
- Hyper-flexible joints
- Autism and autistic behaviors
- Social anxiety
- Poor eye contact and Sensory disorders
Normally, no one individual will have all the symptoms of fragile X syndrome. Some of the features only occur in puberty. When it comes to women, here are a few features of FXS to contemplate although they may have similar traits as those seen in men and they include;
- Milder intellectual disabilities
- General anxiety
- Emotional issues
- Hyper-extensible finger joints and thumps
- Large and protruding ears
- Soft skin
- Vertical maxillary excess [long face]
- Hyptonia among others.
Individuals diagnosed with fragile X syndrome may face different challenges in their lives. But they can be quite productive and attractive if presented with the best support and interventions. There are no current treatments of FXS defects, but patients can always seek medications for symptoms based treatments. This helps reduce the secondary features of FXS. Genetic counselling to determine full mutation or permutation is essential. Stimulants that target attentional problems or hyperactivity can aid. Antidepressants, antipsychotics, anticonvulsants and behavioral therapy or educational plans can aid help treat physical abnormalities.
It is commonly the presence of abnormal and uncoordinated muscle movement. It is a neurological sign that infers dysfunction of the parts of the nervous system that aid in coordinating movement. It is a condition that affects the movement of the eye, speech, writing and swallowing and many other activities that depend on motor control.It is a term used broadly to indicate lack of coordination in the core physiological process. There are several types of ataxias that expound more on the disorder and they are;
This is type of ataxia caused by dysfunction of the cerebellum, a region in the brain which aids in the assimilation of sensory coordination, motor control and perception. Cerebellum is responsible for the integrating a substantial amount of neural information that is helpful in coordinating smooth movements and motor control planning. Cerebellar ataxias causes basic neurological problems such as hypotonia, lack of coordination between limbs, joints, organs and muscles, dysdiadochokinesia, dysmetria and dyschronometria.
This is a type of ataxia that is as a result of loss of proprioception, the sense of relative position of nearby parts of the body. It is a kind of sense that points out whether the body is moving as required and where the body parts are located in relation to each other. Dysfunction of the dorsal columns of the spinal cord cause sensory ataxia as they carry proprioceptive messages up to the brain. Sensory ataxia is characterized by postural instability, unsteady stomping gait accompanied by heavy heel strikes.
It occurs due to the dysfunction of the vestibular system. it is a condition associated with nausea, vomiting and vertigo. Patients are known to experience unsteadiness and giddiness.
Its Symptoms and signs vary depending on the severity and the type of ataxia one may be suffering from and they are many. For instance, if ataxia is caused by an injury or health complications symptoms may occur at any age, improve and eventual disappear undyingly. The initial symptoms of ataxia include;
- Poor limb and joint coordination
- Slurred and slow speech accompanied by difficulty in controlling volume, pitch and rhythm
- Swallowing problems
- Less apparent facial expressions
- Cold feet
- Walking complications
- Hearing problem and
Deficiency of Vitamin B12 and neurological abnormalities can cause sensory ataxia and overlapping cerebellar. Genetic flaws easily inherited from mother or father or both can cause inherited ataxia. This gene can be passed from one generation to the next. Procedures such as brain surgery, alcohol abuse, head injury, drug abuse, brain tumor, chicken pox and multiple sclerosis can all cause different types of ataxia.
A neurologist can easily diagnose and offer the best treatment and prevent measures. While diagnosing ataxia, the specialist will check patient’s medical history and either conduct tests such as Magnetic resonance imaging [MRI] or computerized tomography [CT] scan. Blood, urine and genetic tests are essential in determining whether the patient as any signs of ataxia.
Is not treatable, but a great deal can be undertaken to ease the its symptoms and improve life of the patient. There are several adaptive devices that patients can use and treat coordination and balance difficulties. This includes use of wheelchair, walking sticks and crutches. Other symptoms can be treated through physical therapy, speech and occupational therapy, orthopedic care and extensive counselling. Medications such as gamma-globulin injection can aid patients with ataxia telangiectasia.
Consumer movement refers to the effort of consumer protection promotion through a social movement that is organized and which exists in several places. Usually, consumer organizations are at the front position of such a movement. It also advocates consumer rights especially those that are infringed through actions taken by governments, organizations or other firms that provide services and goods to consumers.
Where it started
The first conference on an international scale was held in 1960 March in The Hague. Several consumer organizations participated in the conference and five of these signed papers creating the International Organization of Consumers Unions (IOCU). Consequently, as a result of that conference, the global movement was formed.
The term “consumer movement” is used in writing and is comparable to “consumerism”. Consumerism is a traditional term and one that is practiced by modern day age consumer organizations. It refers to progression of consumer protection which includes passing of customer protection laws by legislators.
Additionally, it includes educators teaching consumer policy, product testers who ensure products are within the desired quality standards and regulators who policy consumer laws. Note that consumer movement is non-profit group and it promotes the interests of consumers through reformation of practices upheld by corporations or government policies. Therefore, consumer movement is described as a subset of “consumerism” discipline.
The United States
During the 1960’s, US lobbyists of the Chamber of Commerce and the National Retail Federation begun using “consumerism” referring to the movement in a hostile and depreciatory manner. This was with the aim of denigrating the movement and Esther Peterson’s work in her position as the Special Assistant to the materialism and commercialism President. The term has an ideological foundation and some of the people who were behind the idea of the movement include:
- Ellen Swallow Richards who pioneered home economics
- Upton Sinclair who raised public interest in the protection of consumers
- Herbert Hoover who demanded that products should be tested and insisted on the need for application of technical standards in product manufacture
- Thorstein Veblen who introduced advertising theory and conspicuous consumption concept
Historians recognize the publication “Your Money’s Worth by Stuart Chase and Fredrick J. Schlink as the event that led to establishment of consumer movement. The publication of the book, according to historians was innovative leading to introduction of product testing concept which forms the basis of modern day age consumer movement.
Consumer movement is believed to have its origins in the US. From the 1960’s through to the 70’s scholars started recognizing consumer activism “waves” setting the stage for a whole movement to be born with the purpose of protecting consumer interests.
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Franchising Pros and Cons
To many entrepreneurs who have been successful in building business empires, franchising is an option that may be running through their minds. Franchising is one of the ways of expanding a business and you too may be moved to try it out. However, it is very important to note that just like any other models of business, franchising also has its benefits and demerits. Getting to know them will help you as an entrepreneur to make an informed choice on whether to franchise or not.
One of the pros of franchising is that it can be helpful in obtaining new talent for good business. Many people who are highly qualified and hard workers often tend to invest in running businesses instead of being employed by others in exchange for salaries. Thus, there is a higher chance that by franchising, you are able to get the best talent that can work towards building the business compared to hiring someone to work for you.
Franchising is also a way of obtaining expansion capital for the business without a lot of stress. Since franchisees pay to acquire outlets within the chain, you are able to significantly increase the number of locations without necessarily having to tap a great chunk of your own capital or even moving up and down in search of loans from banks.
When making comparison between starting your own business and franchising, you will realize that franchising is less risky and even costly. Since franchising involves the use of a brand that is already established in the market, there are several costs that are already avoided. Besides, it should also be noted that even though franchisors do not provide financing, many have better working relationships with lenders that can help with issues about financing.
Franchising limits creativity and flexibility on the part of the entrepreneur who is franchising. The reason for this is because the contracts always come with rules that set very explicit standards. In most occasions, the investor who has franchised is not allowed to make any change to the brand but stick to what its owner stipulates. Even if you have a new idea, the franchisor has to agree to it before it is rolled out. This can curtail the efforts of the franchisee to develop the business in the way that he or she likes.
Another con of franchising is that the success of the franchisee is based on the franchisor. The reputation that the franchisee will have in the market shall be a representation of the franchisor’s. This means that any problem that is encountered by the franchisor in the course of doing business will directly impact the franchisee. In fact, investors who fail to do their research well before franchising always find themselves stuck for years after signing the contract.
Just like any other ventures that people may think of investing in, there is no guarantee that franchising is risk-free and more profitable. Choosing to franchise or not is a decision that requires proper research and consultations.
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Pros and Cons of Peer to Peer File Sharing
There many pros and cons of peer to peer file sharing. Peer to peer file sharing refers to sharing of files in a network of connected personal computers. The connected computers share resources in a network that does not involve a separate computer acting as a server.
Peer to peer file sharing is a strategy that is gaining popularity among software corporations. Although this strategy has proved to be beneficial to companies, it has some faults or disadvantages as well. Among the pros of peer to peer file sharing include its easy installation.
Installing peer to peer file sharing network is easy. Computers that are involved in this network are also easy to configure. Thus, it is suitable for companies that do not have a lot of time to spend in installing a file sharing network. If a company does not have an in-house IT department it can also use this network.
In this network, all contents and resources are shared by all peers. This is not the case with server-client network where the server shares the content and resources. This implies that as long as a computer is in the network it can access all files, contents or resources of the architecture.
Peer to peer file sharing network eliminates central dependency. This makes it more reliable because if one peer fails the entire system is not affected. Other peers continue functioning properly when one peer fails. This is not the case with a client-server architecture where the entire system goes down when the server fails.
In addition, peer to peer network does not require a system administrator all the time. The system makes every peer an administrator of their computer. Users are able to control their resources or the shared files. Establishing and maintaining a peer to peer file sharing network is also relatively cheaper.
Among the cons of peer to peer file sharing network include the decentralization of the entire system. This makes administering the system difficult because a single administrator cannot determine the entire accessibility of the settings of the whole network.
The entire network is also not secure. This is because peers can transmit spywares, viruses, malwares and Trojans. These threats can spread from one peer to the other very easily since in most cases nobody monitors the system.
Backup or data recovery is also difficult in a peer to peer file sharing network. Each computer in the network should have a backup system of its own. Peer to peer file sharing network is also not necessarily legal. For this reason, copyrighted files such as music and movies are easily transferred via this network. A good example of this is torrents that use peer to peer file sharing technology.
Generally, peer to peer file sharing network is good when used in connecting a small number of computers and where high security level is not necessary. However, in business networks where there is availability of sensitive data, peer to peer file sharing network is not suitable.
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Armada is a popular Spanish word for a fleet. In 1588, the most fortunate fleet in Spain, the la felicissima armada, made up of 150 Spanish, Portuguese and Naples ships was made. This was the largest fleet of the time across Europe and it was considered invincible by Phillip II of Spain. A description of the fleet was later published in Europe with a main goal of spreading fear amongst the enemies of Spain.
Planning of the Armada Campaign
Planning of the Armada campaign was done by King Phillip II of Spain. He came up with the plan as he intended to sail with his army and navy up the English Channel. The group of about 30,000 men wanted to link up with forces in the Spanish Netherlands led up by the Duke of Parma. They also planned to invade England and spread Catholicism across the region.
Why invade England
King Phillip II had different reasons for invading England. He wanted to put an end to religious differences between the two countries, expansion in the new world of Americans and competition for trade in the region. These were his major reasons among others.
Mary queen of Scots and claim over the rule of England
As a child, Mary had been brought up in a catholic background in France but returned to Scotland to rule. Her grandmother was the sister of Henry VIII and after she suspected that there was a plot to kill her husband Lord Darnley, she fled to England and was imprisoned for 18yrs. This is because Queen Elizabeth feared any plots against her throne.
In 1586, Mary Queen of Scots was executed sending shivers across Catholic Europe. This is an event that also added up to the reasons as to why King Phillip II wanted to invade England in a bid to avenge the killing of the queen.
King Phillip also wanted to help sea beggars and by invading England, he would easily achieve his goals. The Sea Beggars was a small group of noblemen Protestants determined to drive Spanish out of Netherlands. They led a revolt against Spanish occupation under the leadership of William and later on his son Justin of Nassau after his father died.
During the resign of Mary I of England, Sailor Sir Francis Drake enraged King Phillip. It is during the same period that England expanded its trade activities in 1560s and 1570s while building a strong navy. Francis Drake therefore joined the navy as a very young boy and made his name by attacking different treasure ships sailing from America to Spain.
However, his daring act was in 1586 when he set alight Spanish ships in Cadiz harbor with an aim to singe the King of Spain’s beard. This angered King Phillip and added up to his reasons to invade England. He then established a strong superiority navy under the Spanish Armada to spread Catholicism in England.
The Duke of Medina Sidonia was elected the commander of the great Armada and on board, was army soldiers ready to invade England. They fought a fierce battle before and during a stormy weather that destroyed many ships. 65 out of 150 ships in the Armada returned to Lisbon.
The Long March
The Long March started in 1934 October and lasted till 1935 October. It was the most historic six thousand miles journey by the Red Army which was China’s Communist Party. It wasn’t just one Long March rather, a series of marches as Communist armies made an escape to the West and North. Eighty thousand soldiers were part of the walk but roughly, only eight thousand or nine thousand made it through the trek. At the end of the trek a Communist base was established in Yan’an and the March became the focal point of events in the mythology of Chinese revolutionary.
The march that is best known was the one from the province of Jiangxi which commenced in 1934 October. At that time, the First Front Army was close to annihilation by troops belonging to Generalissimo Chiang Kai-shek’s troops all this within their stronghold because the army was led by a military commission that was inexperienced. Under Mao Zedong and Zhou Enlai leadership, the communists managed to escape in a retreat to the north and west. They walked for nine thousand kilometers in three hundred and seventy days. The route used by the communists was the trickiest terrain in west China as they first traveled west then later North finding their way to Shaanxi.
The commencement of the March was after Mao Zedong ascension to power. The leadership of Zadong at the time of retreat helped him gain support from party members. The March was a bitter struggle and one that only one-tenth of the army managed to complete. It represented a significant chapter in history of Communist party and sealed the prestige of Mao as well as his supporters in the decades that followed. However, it is important to note the role of Mao is a disputed one with many claiming his role was not just exaggerated but that certain events were completely fabricated.
After making an escape from the Chiang encirclement, it became obvious to leaders of the party that the intention of Chiang was interception of what still remained of Red Army hence they had to make reconsiderations regarding the route the army should take. They made a rendezvous plan with the aim of joining Hunan’s He Long’s army.
Mao was the one who made the suggestion the Red Army should change direction and head towards Guizhou where he believed defenses of the enemy would be weak. To make the decision on which direction the Red Army should follow, on 12th December, 1934 a meeting was convened at Tongdao which was close to the Guizhou and Hunan border. The proposal made by Mao was endorsed by Zhou thus overruling objections raised by Braun and Bo.
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